Systemically administered glucosamine-kynurenic acid, but not pure kynurenic acid, is effective in decreasing the evoked activity in area CA1 of the rat hippocampus
The metabolism of tryptophan along the kynurenine pathway yields several neuroactive intermediates, including kynurenic acid, which is one of the few known endogenous N-methyl-D-aspartate receptor inhibitors; in parallel with this, it is an alpha 7 nicotinic acetylcholinergic receptor antagonist. On...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2005
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| Sorozat: | EUROPEAN JOURNAL OF PHARMACOLOGY
513 |
| doi: | 10.1016/j.ejphar.2005.02.043 |
| mtmt: | 1029486 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10090 |