Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats
In the present experiment unilateral intrastriatal injections of aminooxyacetic acid (1, 2.5, 5 mumol) to freely moving animals and pentobarbital-anesthetized rats produced contralateral jerks and dose-dependent mortality, but no barrel rotation. At 10-12 days there were no significant differences i...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | EUROPEAN JOURNAL OF PHARMACOLOGY
220 |
| doi: | 10.1016/0014-2999(92)90756-T |
| mtmt: | 1032278 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10550 |
| Tartalmi kivonat: | In the present experiment unilateral intrastriatal injections of aminooxyacetic acid (1, 2.5, 5 mumol) to freely moving animals and pentobarbital-anesthetized rats produced contralateral jerks and dose-dependent mortality, but no barrel rotation. At 10-12 days there were no significant differences in exploratory activity, passive avoidance behavior, and elevated plus-maze test in aminooxyacetic acid-treated animals as compared with controls. However freely moving animals microinjected with aminooxyacetic acid (but not the pentobarbital-pretreated group) had impaired learning activity in an active avoidance conditioning test, and showed reduced striatal concentrations of substance P and GABA. Intrastriatal injections of aminooxyacetic acid therefore result in both acute and chronic behavioral changes which are attenuated by pentobarbital anesthesia. |
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| Terjedelem/Fizikai jellemzők: | 259-262 |
| ISSN: | 0014-2999 |