Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model

Nitroglycerin, often used as a migraine model, results in increased number of c-fos immunoreactive secondary sensory neurons in the caudal trigeminal nucleus. Since synapses between first- and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are presumably inhib...

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Bibliographic Details
Main Authors: Knyihár-Csillik Erzsébet
Toldi József
Mihály András
Krisztinné Péva Beáta
Chadaide Zoltán
Németh Hajnalka
Fenyő Róbert
Vécsei László
Format: Article
Published: Springer-Verlag 2007
Series:JOURNAL OF NEURAL TRANSMISSION 114 No. 4
doi:10.1007/s00702-006-0545-z

mtmt:1031439
Online Access:http://publicatio.bibl.u-szeged.hu/9999
Description
Summary:Nitroglycerin, often used as a migraine model, results in increased number of c-fos immunoreactive secondary sensory neurons in the caudal trigeminal nucleus. Since synapses between first- and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are presumably inhibited by kynurenic acid, the only known endogeneous NMDA receptor antagonist. Although kynurenic acid does not cross the BBB, its precursor, kynurenine, if combined with probenecid, crosses it readily. Systemic kynurenine + probenecid treatment significantly diminishes nitroglycerin-induced increase of c-fos immunoreactivity in the brainstem.
Physical Description:417-421
ISSN:0300-9564