Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis

Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis

Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction a...

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Bibliographic Details
Main Authors: Losonczi Erika
Bencsik Krisztina
Fricska-Nagy Zsanett
Honti Viktor
Szalczer Estilla
Rajda Cecília
Illés Zsolt László
Mátyás Klotild
Rózsa Csilla
Csépány Tünde
Füvesi Judit
Vécsei László
Format: Article
Published: 2009
Series:JOURNAL OF NEUROIMMUNOLOGY 208 No. 1-2
doi:10.1016/j.jneuroim.2009.01.004

mtmt:1230928
Online Access:http://publicatio.bibl.u-szeged.hu/9950
Description
Summary:Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p=0.027; p=0.032). The G allele may be one of the factors responsible for progression in PPMS.
Physical Description:115-118
ISSN:0165-5728

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