Recent advances in the stereoselective syntheses of acyclic disubstituted β2,3-amino acids
Abstract A wide variety of synthetic protocols have been developed during the past twenty years to the access of β2,3-amino acids as biologically interesting scaffolds in medicinal chemistry. The current account is devoted to provide an insight of the most relevant synthetic routes to this class of...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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2015
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| Sorozat: | TETRAHEDRON
71 No. 14 |
| doi: | 10.1016/j.tet.2015.01.060 |
| mtmt: | 2840227 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9905 |
| Tartalmi kivonat: | Abstract A wide variety of synthetic protocols have been developed during the past twenty years to the access of β2,3-amino acids as biologically interesting scaffolds in medicinal chemistry. The current account is devoted to provide an insight of the most relevant synthetic routes to this class of derivatives in racemic or enatiomerically pure form. The highlight focuses on the presentation of the stereoselective and stereocontrolled methodologies in view of efficiency and versatility, as well as limitations concerning stereocontrol, selectivity or large-scale synthesis. Relevant biological properties of these types of substances are also presented. |
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| Terjedelem/Fizikai jellemzők: | 2049-2069 |
| ISSN: | 0040-4020 |