Genetic polymorphisms of human beta-defensins in patients with ischemic stroke
Tiszlavicz Z, Somogyvari F, Szolnoki Z, Sztriha LK, Nemeth B, Vecsei L, Mandi Y. Genetic polymorphisms of human beta-defensins in patients with ischemic stroke. ?Acta Neurol Scand: 2012: 126: 109115. (C)2011 John Wiley & Sons A/S. Objectives and Methods Genetic predisposition of the inflammatory...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2012
|
| Sorozat: | ACTA NEUROLOGICA SCANDINAVICA
126 No. 2 |
| doi: | 10.1111/j.1600-0404.2011.01613.x |
| mtmt: | 2032048 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9882 |
| Tartalmi kivonat: | Tiszlavicz Z, Somogyvari F, Szolnoki Z, Sztriha LK, Nemeth B, Vecsei L, Mandi Y. Genetic polymorphisms of human beta-defensins in patients with ischemic stroke. ?Acta Neurol Scand: 2012: 126: 109115. (C)2011 John Wiley & Sons A/S. Objectives and Methods Genetic predisposition of the inflammatory host response may affect the development of stroke. On the basis of the theory of infectious burden and risk of stroke, we considered it of interest to investigate the relevance of the single-nucleotide polymorphisms (SNPs) in the DEFB1 gene and the copy number variant (CNV) of the DEFB4 genes in ischemic stroke. Results There were no significant differences in the genotype frequencies of the three SNPs of the DEFB1 gene between the patients with stroke (n = 312) and the healthy blood donors (n = 221). However, a higher frequency of a lower (<4) copy number of the DEFB4 gene was observed in the patients with ischemic stroke as compared with the healthy controls (40% vs 24%, respectively). Additionally, low plasma concentrations of hBD-2 (187 +/- 20 pg/ml) were characteristic of the patients with fewer than four copy numbers relative to those with more than four copy numbers (385 +/- 35 pg/ml). Conclusions The low copy number of the DEFB4 gene, involving a weakened antimicrobial defense of the host, might be important in the pathogenesis of stroke. |
|---|---|
| Terjedelem/Fizikai jellemzők: | 109-115 |
| ISSN: | 0001-6314 |