Effect of herpesvirus infection on pancreatic duct cell secretion
Incubation with the BDG or KEG strains of PRV results in an effective infection of ductal epithelial cells. The BDG strain of PRV, which is able to initiate a lytic viral cycle, stimulates HCO(3)(-) secretion in guinea pig pancreatic duct by about four- to fivefold, 24 h after the infection. However...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2005-10-14
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| Sorozat: | World journal of gastroenterology
11 No. 38 |
| doi: | 10.3748/wjg.v11.i38.5997 |
| mtmt: | 1082040 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9048 |
| Tartalmi kivonat: | Incubation with the BDG or KEG strains of PRV results in an effective infection of ductal epithelial cells. The BDG strain of PRV, which is able to initiate a lytic viral cycle, stimulates HCO(3)(-) secretion in guinea pig pancreatic duct by about four- to fivefold, 24 h after the infection. However, the KEG strain of PRV, which can infect, but fails to replicate, has no effect on HCO(3)(-) secretion. We suggest that this response of pancreatic ducts to virulent PRV infection may represent a defense mechanism against invasive pathogens to avoid pancreatic injury. |
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| Terjedelem/Fizikai jellemzők: | 5997-6002 |
| ISSN: | 1007-9327 |