A novel transgenic rabbit model with reduced repolarization reserve long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene /

We have created a novel transgenic LQT5 rabbit model with increased susceptibility to drug-induced arrhythmias that may represent a useful model for testing proarrhythmic potential and for investigations of the mechanisms underlying arrhythmias and sudden cardiac death due to repolarization disturba...

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Bibliographic Details
Main Authors: Major Péter
Baczkó István
Hiripi László
Odening Katja E.
Juhász Viktor
Kohajda Zsófia
Horváth András
Seprényi György
Kovács Mária
Virág László
Jost Norbert László
Prorok János
Ördög Balázs
Doleschall Zoltán
Nattel Stanley
Varró András
Bősze Zsuzsanna
Format: Article
Published: 2016
Series:British journal of pharmacology 173 No. 12
doi:10.1111/bph.13500

mtmt:3052278
Online Access:http://publicatio.bibl.u-szeged.hu/9047
Description
Summary:We have created a novel transgenic LQT5 rabbit model with increased susceptibility to drug-induced arrhythmias that may represent a useful model for testing proarrhythmic potential and for investigations of the mechanisms underlying arrhythmias and sudden cardiac death due to repolarization disturbances.
Physical Description:2046-2061
ISSN:1476-5381