Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling

Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling

CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca(2+) entry, and enhancing atrial fibroblast proliferation. These effects are likely mediated by microRNA-26a downregulation. Remodeling-induced fibroblast KCNJ2 expression changes may play a role in a...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Qi Xiao-Yan
Huang Hai
Ördög Balázs
Luo Xiaobin
Naud Patrice
Sun Yiguo
Wu Chia-Tung
Dawson Kristin
Tadevosyan Artavazd
Chen Yu
Harada Masahide
Dobrev Dobromir
Nattel Stanley
Dokumentumtípus: Cikk
Megjelent: 2015-02-27
Sorozat:Circulation research 116 No. 5
doi:10.1161/CIRCRESAHA.116.305326

mtmt:2826704
Online Access:http://publicatio.bibl.u-szeged.hu/9042
Leíró adatok
Tartalmi kivonat:CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca(2+) entry, and enhancing atrial fibroblast proliferation. These effects are likely mediated by microRNA-26a downregulation. Remodeling-induced fibroblast KCNJ2 expression changes may play a role in atrial fibrillation promoting fibroblast remodeling and structural/arrhythmic consequences.
Terjedelem/Fizikai jellemzők:836-45
ISSN:1524-4571

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