Unique cardiac Purkinje fiber transient outward current β-subunit composition a potential molecular link to idiopathic ventricular fibrillation. /

These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation.

Elmentve itt :
Bibliográfiai részletek
Szerzők: Xiao Ling
Koopmann Tamara T.
Ördög Balázs
Postema Pieter G.
Verkerk Arie O.
Iyer Vivek
Sampson Kevin J.
Boink Gerard J. J.
Mamarbachi Maya A.
Varró András
Jordaens Luc
Res Jan
Kass Robert S.
Wilde Arthur A.
Bezzina Connie R.
Nattel Stanley
Dokumentumtípus: Cikk
Megjelent: 2013-05-10
Sorozat:Circulation research 112 No. 10
doi:10.1161/CIRCRESAHA.112.300227

mtmt:2244228
Online Access:http://publicatio.bibl.u-szeged.hu/9040
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520 3 |a These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation. 
700 0 1 |a Koopmann Tamara T.  |e aut 
700 0 1 |a Ördög Balázs  |e aut 
700 0 1 |a Postema Pieter G.  |e aut 
700 0 1 |a Verkerk Arie O.  |e aut 
700 0 1 |a Iyer Vivek  |e aut 
700 0 1 |a Sampson Kevin J.  |e aut 
700 0 1 |a Boink Gerard J. J.  |e aut 
700 0 1 |a Mamarbachi Maya A.  |e aut 
700 0 1 |a Varró András  |e aut 
700 0 1 |a Jordaens Luc  |e aut 
700 0 1 |a Res Jan  |e aut 
700 0 1 |a Kass Robert S.  |e aut 
700 0 1 |a Wilde Arthur A.  |e aut 
700 0 1 |a Bezzina Connie R.  |e aut 
700 0 1 |a Nattel Stanley  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/9040/7/2244228.pdf  |z Dokumentum-elérés