Unique cardiac Purkinje fiber transient outward current β-subunit composition a potential molecular link to idiopathic ventricular fibrillation. /

Unique cardiac Purkinje fiber transient outward current β-subunit composition a potential molecular link to idiopathic ventricular fibrillation. /

These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation.

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Bibliographic Details
Main Authors: Xiao Ling
Koopmann Tamara T.
Ördög Balázs
Postema Pieter G.
Verkerk Arie O.
Iyer Vivek
Sampson Kevin J.
Boink Gerard J. J.
Mamarbachi Maya A.
Varró András
Jordaens Luc
Res Jan
Kass Robert S.
Wilde Arthur A.
Bezzina Connie R.
Nattel Stanley
Format: Article
Published: 2013-05-10
Series:Circulation research 112 No. 10
doi:10.1161/CIRCRESAHA.112.300227

mtmt:2244228
Online Access:http://publicatio.bibl.u-szeged.hu/9040
Description
Summary:These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation.
Physical Description:1310-22
ISSN:1524-4571

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