Unique cardiac Purkinje fiber transient outward current β-subunit composition a potential molecular link to idiopathic ventricular fibrillation. /
These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation.
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2013-05-10
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| Sorozat: | Circulation research
112 No. 10 |
| doi: | 10.1161/CIRCRESAHA.112.300227 |
| mtmt: | 2244228 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9040 |
| Tartalmi kivonat: | These results point to a previously unknown central role of DPP6 in PF I(to), with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation. |
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| Terjedelem/Fizikai jellemzők: | 1310-22 |
| ISSN: | 1524-4571 |