Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts
Prolonged β1-adrenoceptor stimulation suppresses IKs by downregulating KCNE1 mRNA and protein via Epac-mediated Ca(2+)/calcineurin/NFAT signaling. These results provide new insights into the molecular basis of K(+) channel remodeling under sustained adrenergic stimulation.
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2014
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| Sorozat: | Circulation research
114 No. 6 |
| doi: | 10.1161/CIRCRESAHA.113.302982 |
| mtmt: | 2535107 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8368 |
| Tartalmi kivonat: | Prolonged β1-adrenoceptor stimulation suppresses IKs by downregulating KCNE1 mRNA and protein via Epac-mediated Ca(2+)/calcineurin/NFAT signaling. These results provide new insights into the molecular basis of K(+) channel remodeling under sustained adrenergic stimulation. |
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| Terjedelem/Fizikai jellemzők: | 993-1003 |
| ISSN: | 1524-4571 |