Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents
Abstract 13α-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431). Compounds with N-benzyltriazolylmethoxy m...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | STEROIDS
113 |
| doi: | 10.1016/j.steroids.2016.05.010 |
| mtmt: | 3078352 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8289 |
| Tartalmi kivonat: | Abstract 13α-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431). Compounds with N-benzyltriazolylmethoxy moieties on C-3 proved to be more potent than their 3-hydroxy or 3-ether counterparts. Some triazoles exerted substantial cytostatic effects against particular tumor cell lines, with submicromolar IC50 values. |
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| Terjedelem/Fizikai jellemzők: | 14-21 |
| ISSN: | 0039-128X |