Chain-length-dependent helical motifs and self-association of beta-peptides with constrained side chains

Homo-oligomers constructed by using trans-2-aminocyclohexanecarboxylic acid monomers without protecting groups were studied. Both ab initio theory and NMR measurements showed that the tetramer tends to adopt a 10-helix motif, while the pentamer and hexamer form the known 14-helix. It was concluded t...

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Bibliographic Details
Main Authors: Hetényi Anasztázia
Mándity István M.
Martinek Tamás A.
Tóth Gábor
Fülöp Ferenc
Format: Article
Published: American Chemical Society 2005
Series:JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127 No. 2
doi:10.1021/ja0475095

mtmt:1012850
Online Access:http://publicatio.bibl.u-szeged.hu/7562
Description
Summary:Homo-oligomers constructed by using trans-2-aminocyclohexanecarboxylic acid monomers without protecting groups were studied. Both ab initio theory and NMR measurements showed that the tetramer tends to adopt a 10-helix motif, while the pentamer and hexamer form the known 14-helix. It was concluded that the conformationally constrained backbone is flexible enough to afford both 10-helical and 14-helical motifs, this observation in turn providing evidence of the true folding process. Self-association or the helical units was also detected, and the results of variable-temperature diffusion NMR measurements strongly suggested the presence of helical bundles in methanol solution.
Physical Description:547-553
ISSN:0002-7863