Chain-length-dependent helical motifs and self-association of beta-peptides with constrained side chains
Homo-oligomers constructed by using trans-2-aminocyclohexanecarboxylic acid monomers without protecting groups were studied. Both ab initio theory and NMR measurements showed that the tetramer tends to adopt a 10-helix motif, while the pentamer and hexamer form the known 14-helix. It was concluded t...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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American Chemical Society
2005
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| Sorozat: | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
127 No. 2 |
| doi: | 10.1021/ja0475095 |
| mtmt: | 1012850 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/7562 |
| Tartalmi kivonat: | Homo-oligomers constructed by using trans-2-aminocyclohexanecarboxylic acid monomers without protecting groups were studied. Both ab initio theory and NMR measurements showed that the tetramer tends to adopt a 10-helix motif, while the pentamer and hexamer form the known 14-helix. It was concluded that the conformationally constrained backbone is flexible enough to afford both 10-helical and 14-helical motifs, this observation in turn providing evidence of the true folding process. Self-association or the helical units was also detected, and the results of variable-temperature diffusion NMR measurements strongly suggested the presence of helical bundles in methanol solution. |
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| Terjedelem/Fizikai jellemzők: | 547-553 |
| ISSN: | 0002-7863 |