Self-association-driven transition of the beta-peptidic H12 helix to the H18 helix

Various patterns of foldameric oligomers formed by trans-ABHC ((1S,2S,3S, 5S)-2-amino-6,6-dimethylbicyclo-[3.3.1]heptane-3-carboxylic acid) and beta(3)-hSer residues were studied. NMR, ECD and molecular modelling demonstrated that octameric and nonameric sequences with multiple i-i+3 ABHC pair repul...

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Bibliographic Details
Main Authors: Szolnoki Éva Tünde
Hetényi Anasztázia
Martinek Tamás A.
Szakonyi Zsolt
Fülöp Ferenc
Format: Article
Published: Royal Society of Chemistry Publishing 2012
Series:ORGANIC & BIOMOLECULAR CHEMISTRY 10 No. 2
doi:10.1039/c1ob06627g

mtmt:1842289
Online Access:http://publicatio.bibl.u-szeged.hu/7546
Description
Summary:Various patterns of foldameric oligomers formed by trans-ABHC ((1S,2S,3S, 5S)-2-amino-6,6-dimethylbicyclo-[3.3.1]heptane-3-carboxylic acid) and beta(3)-hSer residues were studied. NMR, ECD and molecular modelling demonstrated that octameric and nonameric sequences with multiple i-i+3 ABHC pair repulsions attain the beta-H18 helix in CD3OH. As a close relative of the alpha-helix, this helix type is stabilized by i-i+4 backbone H-bond interactions. The formation of the beta-H18 helix was found to be solvent-and concentration-dependent. Upon dilution, the beta-H18 -> beta-H12 helix transition was revealed by concentration-dependent ECD, DOSY-NMR and TEM measurements.
Physical Description:255-259
ISSN:1477-0520