In vitro antiproliferative activity of flavonols Fisetin, quercetin and kaempferol and their cyclodextrin complexes /

The aim of this study was to evaluate the in vitro antiproliferative capacity of the flavonols: fisetin, quercetin and kaempferol alone and incorporated in β-cyclodextrins, on A2780 (human ovarian carcinoma cells), MDA-MB-231 (human breast cancer cells) and SiHa (human cervix cancer cells). On the s...

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Bibliographic Details
Main Authors: Danciu Corina
Citu Cosmin
Zupkó István
Ghiulai Roxana
Matusz Petru
Pavel Zinuca Ioana
Popescu Alexandra
Pinzaru Iulia
Simu Georgeta
Daliborca Vlad C
Format: Article
Published: Asociata Medicala Romana 2015
Series:FARMACIA (BUCHAREST) 63 No. 6
mtmt:2998565
Online Access:http://publicatio.bibl.u-szeged.hu/6937
Description
Summary:The aim of this study was to evaluate the in vitro antiproliferative capacity of the flavonols: fisetin, quercetin and kaempferol alone and incorporated in β-cyclodextrins, on A2780 (human ovarian carcinoma cells), MDA-MB-231 (human breast cancer cells) and SiHa (human cervix cancer cells). On the selected cell lines, among the tested compounds, fisetin was the most active in terms of antiproliferative activity. The most sensitive cell line to the tested flavonols was found to be the human ovarian carcinoma A2780 cell line. The inclusion complexes between the selected flavonols with ramified β-cyclodextrins determined different effects, depending on the cell line and on the tested compound. © 2015, Romanian Society for Pharmaceutical Sciences. All rights reserved.
Physical Description:858-864
ISSN:0014-8237