DermAll nanomedicine for allergen-specific immunotherapy

A novel allergen-specific immunotherapy for IgE-mediated allergies is presented in this paper, using an experimental allergic rhinitis model and a synthetic plasmid pDNA/PEIm nanomedicine expressing ovalbumin as model allergen. Over 50% reduction of symptoms was found as the immune system's bal...

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Bibliographic Details
Main Authors: Garaczi Edina
Szabó Kornélia Ágnes
Francziszti László
Csiszovszki Zsolt
Lőrincz Orsolya
Tőke Enikő R.
Molnár Levente
Bitai Tamás
Jánossy Tamás
Csörgő Sándorné Bata Zsuzsanna
Kemény Lajos
Lisziewicz Julianna
Format: Article
Published: Elsevier 2013-11
Series:Nanomedicine: Nanotechnology, Biology and Medicine 9 No. 8
doi:10.1016/j.nano.2013.05.011

mtmt:2397277
Online Access:http://publicatio.bibl.u-szeged.hu/4073
Description
Summary:A novel allergen-specific immunotherapy for IgE-mediated allergies is presented in this paper, using an experimental allergic rhinitis model and a synthetic plasmid pDNA/PEIm nanomedicine expressing ovalbumin as model allergen. Over 50% reduction of symptoms was found as the immune system's balance was favorably altered toward more TH2-polarized immune responses.
Physical Description:1245-1254
ISSN:1549-9634