Impact of Newly Introduced Population-based Screening and the COVID-19 Pandemic on Colorectal Cancer Incidence and Characteristics - retrospective cohort study
In Hungary, population-based colorectal cancer (CRC) screening was introduced shortly before the onset of COVID-19 pandemic. We aimed to assess the combined impact of these two factors on the incidence and characteristics of CRC.The retrospective cohort study included all patients with newly diagnos...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2026
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| Sorozat: | CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
17 No. 4 |
| Tárgyszavak: | |
| doi: | 10.14309/ctg.0000000000001004 |
| mtmt: | 36968903 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/39419 |
| Tartalmi kivonat: | In Hungary, population-based colorectal cancer (CRC) screening was introduced shortly before the onset of COVID-19 pandemic. We aimed to assess the combined impact of these two factors on the incidence and characteristics of CRC.The retrospective cohort study included all patients with newly diagnosed CRC between 2014 and 2023 and divided into pre-pandemic with screening (2015-2016, 2019), pre-pandemic without screening (2014, 2017-2018), pandemic (2020-2021), and post-pandemic (2022-2023) subgroups. CRC incidence, diagnostic patterns, and tumor stage were compared across subgroups.Crude CRC incidence in institution's care area was lower during pandemic (102.51 per 100,000) compared with the pre-pandemic with screening (117.92 per 100,000; p=0.060) and post-pandemic (120.60 per 100,000; p=0.044) subgroups. Age-standardized incidence differed significantly only between the pre-pandemic with screening and pandemic subgroups (125.30 vs. 105.88 per 100,000; p<0.001). During pandemic, the proportion of early-stage (AJCC 0-I) cancers was significantly reduced compared with the pre-pandemic with screening subgroup (18.74% vs. 25.08%; p=0.048) and the proportion of T1 cancers was also lower compared with the post-pandemic subgroup (6.90 vs. 12.2%; p=0.026). During pandemic, both the annual number of colonoscopies (2,706.00) and the mean number of colonoscopies required to detect one CRC (15.56) were markedly lower compared with the pre-pandemic with screening (4,590.67 and 13.97), pre-pandemic without screening (3,824.33 and 10.67), and post-pandemic (4,573.50 and 15.50) subgroups.The COVID-19 pandemic was associated with unfavorable changes in CRC epidemiology. Organized screening may have mitigated the negative impact during the pandemic and post-pandemic periods. |
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| Terjedelem/Fizikai jellemzők: | 11 |
| ISSN: | 2155-384X |