Beta-lactamases in anaerobic, intestinal bacteria a narrative review /
Anaerobic bacteria in the human intestinal microbiota play a pivotal role in antibiotic resistance, primarily through the production of beta-lactamases. This narrative review explores the diversity of beta-lactamases found in intestinal anaerobes, their functional characteristics, and clinical impli...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2026
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| Sorozat: | ANAEROBE
97 |
| Tárgyszavak: | |
| doi: | 10.1016/j.anaerobe.2026.103024 |
| mtmt: | 36932837 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/39340 |
| LEADER | 02049nab a2200241 i 4500 | ||
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| 024 | 7 | |a 36932837 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
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| 100 | 1 | |a Dutkiewicz Marion | |
| 245 | 1 | 0 | |a Beta-lactamases in anaerobic, intestinal bacteria |h [elektronikus dokumentum] : |b a narrative review / |c Dutkiewicz Marion |
| 260 | |c 2026 | ||
| 300 | |a 6 | ||
| 490 | 0 | |a ANAEROBE |v 97 | |
| 520 | 3 | |a Anaerobic bacteria in the human intestinal microbiota play a pivotal role in antibiotic resistance, primarily through the production of beta-lactamases. This narrative review explores the diversity of beta-lactamases found in intestinal anaerobes, their functional characteristics, and clinical implications. Species of the genus Bacteroides are major producers, harboring enzymes from Ambler classes A (e.g. CepA, CfxA and CblA), B (e.g. CfiA and CcrA) and D (e.g. OXA-347), with activity ranging from cephalosporinases to carbapenemases and oxacillinases. Other gut members, including Clostridioides difficile, Fusobacterium nucleatum, and Acidaminococcus fermentans, also encode specific beta-lactamases. These enzymes contribute to microbiota resilience following beta-lactam exposure and can protect neighboring bacteria via extracellular degradation. This protective mechanism has inspired therapeutic applications, such as recombinant beta-lactamases (ribaxamase, SYN-006) designed to preserve gut integrity during antibiotic therapy. Understanding these intrinsic resistance mechanisms is essential for optimizing antibiotic stewardship and mitigating the spread of resistance genes. Copyright © 2026. Published by Elsevier Ltd. | |
| 650 | 4 | |a Biológiai tudományok | |
| 700 | 0 | 1 | |a Sóki József |e aut |
| 700 | 0 | 1 | |a Ruppe Etienne |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/39340/1/anaerobe_Soki_-J_2026_1-s2.0-S1075996426000041-main.pdf |z Dokumentum-elérés |