Beta-lactamases in anaerobic, intestinal bacteria a narrative review /
Anaerobic bacteria in the human intestinal microbiota play a pivotal role in antibiotic resistance, primarily through the production of beta-lactamases. This narrative review explores the diversity of beta-lactamases found in intestinal anaerobes, their functional characteristics, and clinical impli...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2026
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| Sorozat: | ANAEROBE
97 |
| Tárgyszavak: | |
| doi: | 10.1016/j.anaerobe.2026.103024 |
| mtmt: | 36932837 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/39340 |
| Tartalmi kivonat: | Anaerobic bacteria in the human intestinal microbiota play a pivotal role in antibiotic resistance, primarily through the production of beta-lactamases. This narrative review explores the diversity of beta-lactamases found in intestinal anaerobes, their functional characteristics, and clinical implications. Species of the genus Bacteroides are major producers, harboring enzymes from Ambler classes A (e.g. CepA, CfxA and CblA), B (e.g. CfiA and CcrA) and D (e.g. OXA-347), with activity ranging from cephalosporinases to carbapenemases and oxacillinases. Other gut members, including Clostridioides difficile, Fusobacterium nucleatum, and Acidaminococcus fermentans, also encode specific beta-lactamases. These enzymes contribute to microbiota resilience following beta-lactam exposure and can protect neighboring bacteria via extracellular degradation. This protective mechanism has inspired therapeutic applications, such as recombinant beta-lactamases (ribaxamase, SYN-006) designed to preserve gut integrity during antibiotic therapy. Understanding these intrinsic resistance mechanisms is essential for optimizing antibiotic stewardship and mitigating the spread of resistance genes. Copyright © 2026. Published by Elsevier Ltd. |
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| Terjedelem/Fizikai jellemzők: | 6 |
| ISSN: | 1075-9964 |