Suppression of the P50 evoked response and neuregulin 1-induced AKT phosphorylation in first-episode schizophrenia
OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes....
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2010
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| Sorozat: | AMERICAN JOURNAL OF PSYCHIATRY
167 No. 4 |
| Tárgyszavak: | |
| doi: | 10.1176/appi.ajp.2009.09050723 |
| mtmt: | 1840702 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/37829 |
| LEADER | 01979nab a2200241 i 4500 | ||
|---|---|---|---|
| 001 | publ37829 | ||
| 005 | 20251020144639.0 | ||
| 008 | 251020s2010 hu o 000 eng d | ||
| 022 | |a 0002-953X | ||
| 024 | 7 | |a 10.1176/appi.ajp.2009.09050723 |2 doi | |
| 024 | 7 | |a 1840702 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kéri Szabolcs | |
| 245 | 1 | 0 | |a Suppression of the P50 evoked response and neuregulin 1-induced AKT phosphorylation in first-episode schizophrenia |h [elektronikus dokumentum] / |c Kéri Szabolcs |
| 260 | |c 2010 | ||
| 300 | |a 444-450 | ||
| 490 | 0 | |a AMERICAN JOURNAL OF PSYCHIATRY |v 167 No. 4 | |
| 520 | 3 | |a OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes. METHOD: The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts. RESULTS: Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation. CONCLUSION: Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Beniczky Sándor |e aut |
| 700 | 0 | 1 | |a Kelemen Oguz |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/37829/1/184070256.2010AmJPsych-P50-Neuregulin.pdf |z Dokumentum-elérés |