Suppression of the P50 evoked response and neuregulin 1-induced AKT phosphorylation in first-episode schizophrenia
OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes....
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2010
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| Sorozat: | AMERICAN JOURNAL OF PSYCHIATRY
167 No. 4 |
| Tárgyszavak: | |
| doi: | 10.1176/appi.ajp.2009.09050723 |
| mtmt: | 1840702 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/37829 |
| Tartalmi kivonat: | OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes. METHOD: The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts. RESULTS: Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation. CONCLUSION: Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia. |
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| Terjedelem/Fizikai jellemzők: | 444-450 |
| ISSN: | 0002-953X |