A psychosis szempontjából nagy kockázatú mentális állapotok és kezelésük első hazai eredmények [Low dose antipsychotic treatment reduces the risk of progression to psychosis in persons with prodromalsymptoms: results from Hungary] /
INTRODUCTION: Recent evidence raised the possibility that low-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis. AIMS: To investigate the effectiveness of low-dose antipsychotic medication in the prevention of psychosis. METHODS: Fifty-two pe...
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| Dokumentumtípus: | Cikk |
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2006
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| Sorozat: | ORVOSI HETILAP
147 No. 5 |
| Tárgyszavak: | |
| mtmt: | 1312020 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/37803 |
| Tartalmi kivonat: | INTRODUCTION: Recent evidence raised the possibility that low-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis. AIMS: To investigate the effectiveness of low-dose antipsychotic medication in the prevention of psychosis. METHODS: Fifty-two persons who fulfilled the PACE (Personal Assessment and Crisis Evaluation) criteria of ultra-high risk for psychosis participated in the study. Low-dose antipsychotic treatment (haloperidol or risperidone, 0.5-2 mg/day) was provided for 6 months together with psychoeducation and supportive psychotherapy. Participants were assessed at baseline, 6 months, and 12 months. Antidepressive therapy was provided as needed. RESULTS: Forty-two persons completed the study from whom 3 (7.1%) developed schizophrenia during the 6-month treatment period. New psychotic episodes were not observed during the 6-month follow-up period. Side effects were mild and transient, appearing in the first 4 weeks of treatment. The participants were satisfied with the treatment. CONCLUSIONS: Given that without a specific treatment, 30-60% of persons with ultra-high risk develop frank psychosis, low-dose antipsychotic treatment seems to be effective in the prevention or delay of psychosis. |
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| Terjedelem/Fizikai jellemzők: | 201-204 |
| ISSN: | 0030-6002 |