Inorganic Drugs as a Tool for Protein Structure Solving and Studies on Conformational Changes
Inorganic drugs are capable of tight interactions with proteins through coordination towards aminoacidic residues, and this feature is recognized as a key aspect for their pharmacological action. However, the “protein metalation process” is exploitable for solving the phase problem and structural re...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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2023
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| Sorozat: | CHEMISTRY-A EUROPEAN JOURNAL
29 No. 16 |
| Tárgyszavak: | |
| doi: | 10.1002/chem.202202937 |
| mtmt: | 33773822 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/36614 |
| Tartalmi kivonat: | Inorganic drugs are capable of tight interactions with proteins through coordination towards aminoacidic residues, and this feature is recognized as a key aspect for their pharmacological action. However, the “protein metalation process” is exploitable for solving the phase problem and structural resolution. In fact, the use of inorganic drugs bearing specific metal centers and ligands capable to drive the binding towards the desired portions of the protein target could represent a very intriguing and fruitful strategy. In this context, a theoretical approach may further contribute to solve protein structures and their refinement. Here, we delineate the main features of a reliable experimental-theoretical integrated approach, based on the use of metallodrugs, for protein structure solving. © 2022 Wiley-VCH GmbH. |
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| Terjedelem/Fizikai jellemzők: | 9 |
| ISSN: | 0947-6539 |