Relationship between resonance energy and carcinogenic activity of benz[c]acridines
In order to investigate the correlation between the carcinogenic activity of benz[c]acridines and the electron density, the Huckel orbital method was used. Resonance energies, circuit resonance energies and bond currents of benz[c]acridines were calculated by Aihara's TRE theory. It was shown t...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | ANTICANCER RESEARCH
12 No. 6 B |
| Tárgyszavak: | |
| mtmt: | 2738443 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32261 |
| Tartalmi kivonat: | In order to investigate the correlation between the carcinogenic activity of benz[c]acridines and the electron density, the Huckel orbital method was used. Resonance energies, circuit resonance energies and bond currents of benz[c]acridines were calculated by Aihara's TRE theory. It was shown that these compounds had very stable aromatic characters with positive resonance energies and that the resonance energies per π-electron values for the compounds with lack of the double bond corresponding to the K-region from the parent skeleton were more stable than those of their parent compounds. 7-Methyl-benz[c]acridine derivatives with the methyl groups at 7-, 7, 9-, 7,10-, 7, 11-, 7, 9, 10-, or 7, 9, 11-positions except 5, 7-dimethylbenz[c]acridine had potent carcinogenic activity and significantly lower resonance energy per π-electron. |
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| Terjedelem/Fizikai jellemzők: | 2105-2108 |
| ISSN: | 0250-7005 |