Chemotaxis of freshly separated and cultured human keratinocytes
It is generally accepted that keratinocyte migration plays a critical role in the process of wound healing. A study was therefore made of the migratory response of freshly separated and cultured human keratinocytes to factors with chemotactic properties for a variety of cells. Interleukin-1alpha (IL...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1994
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| Sorozat: | CLINICAL AND EXPERIMENTAL DERMATOLOGY
19 No. 4 |
| Tárgyszavak: | |
| doi: | 10.1111/j.1365-2230.1994.tb01201.x |
| mtmt: | 105842 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/31958 |
| Tartalmi kivonat: | It is generally accepted that keratinocyte migration plays a critical role in the process of wound healing. A study was therefore made of the migratory response of freshly separated and cultured human keratinocytes to factors with chemotactic properties for a variety of cells. Interleukin-1alpha (IL-1alpha), interferon-gamma (IFN-gamma), interleukin-8 (IL-8), and tumour necrosis factor alpha (TNF-alpha) were tested for their chemotactic effectiveness in a modified Boyden chamber assay. IFN-gamma, IL-1alpha and IL-8 were demonstrated to serve as chemoattractants for freshly separated keratinocytes. For cultured cells, however, only IFN-gamma was found to display chemotactic properties. The findings demonstrate that there is significant difference between the chemotactic behaviour of freshly separated and cultured cells. |
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| Terjedelem/Fizikai jellemzők: | 309-311 |
| ISSN: | 0307-6938 |