Planar chromatography of (-)-deprenyl and some structurally related compounds
The thin-layer chromatographic behavior of deprenyl and that of some of its structural analogs has been investigated. R-F values of numerous N-propynyl-N-(2-phenyl-1-methyl)ethylamines are given for characterization of these compounds. Depending on the pH of the aqueous butanol mobile phase, which c...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1998
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| Sorozat: | JPC - JOURNAL OF PLANAR CHROMATOGRAPHY - MODERN TLC
11 No. 4 |
| Tárgyszavak: | |
| mtmt: | 1347397 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/31554 |
| Tartalmi kivonat: | The thin-layer chromatographic behavior of deprenyl and that of some of its structural analogs has been investigated. R-F values of numerous N-propynyl-N-(2-phenyl-1-methyl)ethylamines are given for characterization of these compounds. Depending on the pH of the aqueous butanol mobile phase, which can be regulated by changing the ratio of ammonia to acetic acid, use of elution-type separation enables adequate differentiation of a variety of compounds structurally related to deprenyl, Use of normal-phase silica with triethanolamine containing chloroform as displacer and carrier, respectively, was suitable for displacement separation. Displaced zones were classified as either bona-fide displaced or quasi-displaced bands on the basis of the shape of their displacement train. A useful method is also suggested for establishing the order of any pair of the compounds in the displacement train. TLC on RP-18 silica using both elution and displacement development is also introduced for separation of N-propynyl-N- (2-phenyl-1-methyl)ethylamines and their structural analogs. Advantages of spacer-displacement chromatography are presented. Reversed-phase chromatography on paraffin-coated silica plates serves for determination of lipophilicity; parameters are given as R-M,R-0 values and slopes. |
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| Terjedelem/Fizikai jellemzők: | 247-253 |
| ISSN: | 0933-4173; 1789-0993 |