Az atípusos antipszichotikumok hatékonysága és a dopamin D3-receptor polimorfizmusának kapcsolata schizophreniaban [Relationship between the efficacy of atypical antipsychotics and polymorphism of dopamine d3 receptor in schizophrenia]
OBJECT: Numerous relevant variants of dopamine receptors have been identified in schizophrenia. The Ser9Gly gene polymorphism of dopamine D3 receptor is known as a susceptibility factor for the disease. In addition, it has a role in the modification of therapeutic effect of antipsychotics. In this n...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2002
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| Sorozat: | IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE
55 No. 11-12 |
| Tárgyszavak: | |
| mtmt: | 1312082 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/31146 |
| Tartalmi kivonat: | OBJECT: Numerous relevant variants of dopamine receptors have been identified in schizophrenia. The Ser9Gly gene polymorphism of dopamine D3 receptor is known as a susceptibility factor for the disease. In addition, it has a role in the modification of therapeutic effect of antipsychotics. In this naturalistic study the authors investigated the relationship between this polymorphism and the therapeutic response to atypical antipsychotics. METHOD: 75 patients with schizophrenia according to DSM-IV and 45 healthy controls were recruited. The patients were divided to responder and nonresponder subgroups, cut-off: > 20 point improvement in Global Assessment of Functioning. By polymerase chain reaction the genotype of dopamine D3 receptor of every participant was determined. RESULTS: The Ser9Ser genotype of dopamine D3 receptor was more frequent in the nonresponder subgroup (64%, p = 0.0018). The Ser9 allele was overrepresented among nonresponder patients (82%, p = 0.0172). CONCLUSION: Based on our results, the worse therapeutic response to atypical antipsychotics is associated with Ser9 variant of dopamine D3 receptor. |
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| Terjedelem/Fizikai jellemzők: | 5 377-381 |
| ISSN: | 0019-1442 |