Obtaining and physical-chemical characterization of inclusion complex of a sulphonamidic diuretic with methylated beta-cyclodextrine [Objinerea §i caracterizarea fizico-chimicä a compu§ilor de incluziune ai unui diuretic sulfonamidic cu ß-ciclodextrinä metilatä]
Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-beta-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1: 1, 1:2) an...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2006
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| Sorozat: | REVISTA DE CHIMIE
57 No. 4 |
| Tárgyszavak: | |
| mtmt: | 1883473 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/30630 |
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| 245 | 1 | 0 | |a Obtaining and physical-chemical characterization of inclusion complex of a sulphonamidic diuretic with methylated beta-cyclodextrine [Objinerea §i caracterizarea fizico-chimicä a compu§ilor de incluziune ai unui diuretic sulfonamidic cu ß-ciclodextrinä metilatä] |h [elektronikus dokumentum] / |c Soica C. |
| 260 | |c 2006 | ||
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| 490 | 0 | |a REVISTA DE CHIMIE |v 57 No. 4 | |
| 520 | 3 | |a Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-beta-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1: 1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used in order to obtain the inclusion complexes. Phase solubility diagram of furosemide and RAMEB was constructed and a diagram of A(L) type was obtained, with a stability constant of 130 M-1. The inclusion complexes were analysed by in vitro dissolution tests, differential scanning calorimetry and X-ray diffraction. As water solubility increased, the partition coefficients of the products decreased. | |
| 650 | 4 | |a Kémiai tudományok | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Gyéresi Árpád |e aut |
| 700 | 0 | 1 | |a Aigner Zoltán |e aut |
| 700 | 0 | 1 | |a Kata Mihály |e aut |
| 700 | 0 | 1 | |a Dehelean C. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/30630/1/aok_klny_318_06.pdf |z Dokumentum-elérés |