Obtaining and physical-chemical characterization of inclusion complex of a sulphonamidic diuretic with methylated beta-cyclodextrine [Objinerea §i caracterizarea fizico-chimicä a compu§ilor de incluziune ai unui diuretic sulfonamidic cu ß-ciclodextrinä metilatä]
Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-beta-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1: 1, 1:2) an...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2006
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| Sorozat: | REVISTA DE CHIMIE
57 No. 4 |
| Tárgyszavak: | |
| mtmt: | 1883473 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/30630 |
| Tartalmi kivonat: | Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-beta-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1: 1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used in order to obtain the inclusion complexes. Phase solubility diagram of furosemide and RAMEB was constructed and a diagram of A(L) type was obtained, with a stability constant of 130 M-1. The inclusion complexes were analysed by in vitro dissolution tests, differential scanning calorimetry and X-ray diffraction. As water solubility increased, the partition coefficients of the products decreased. |
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| Terjedelem/Fizikai jellemzők: | 6 392-397 |
| ISSN: | 0034-7752 |