Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase asso...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2022
|
| Sorozat: | SCIENTIFIC REPORTS
12 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1038/s41598-022-22973-9 |
| mtmt: | 33198988 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/29813 |
| LEADER | 03281nab a2200601 i 4500 | ||
|---|---|---|---|
| 001 | publ29813 | ||
| 005 | 20240308081137.0 | ||
| 008 | 240308s2022 hu o 0|| eng d | ||
| 022 | |a 2045-2322 | ||
| 024 | 7 | |a 10.1038/s41598-022-22973-9 |2 doi | |
| 024 | 7 | |a 33198988 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Peduzzi Giulia | |
| 245 | 1 | 0 | |a Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women |h [elektronikus dokumentum] / |c Peduzzi Giulia |
| 260 | |c 2022 | ||
| 300 | |a 8 | ||
| 490 | 0 | |a SCIENTIFIC REPORTS |v 12 No. 1 | |
| 520 | 3 | |a The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involved in oestrogen and pregnenolone biosynthesis and oestrogen-mediated signalling. In the discovery phase 14 polymorphisms showed a statistically significant association (P < 0.05). In the replication none of the findings were validated. In addition, a gene-based analysis was performed on the 208 selected genes. Four genes (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC risk, but only NR5A2 showed an association (P = 4.08 × 10-5) below the Bonferroni-corrected threshold of statistical significance. In conclusion, despite differences in incidence between males and females, our study did not identify an effect of common polymorphisms in the oestrogen and pregnenolone pathways in relation to PDAC susceptibility. However, we validated the previously reported association between NR5A2 gene variants and PDAC risk. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Archibugi Livia |e aut |
| 700 | 0 | 1 | |a Katzke Verena |e aut |
| 700 | 0 | 1 | |a Gentiluomo Manuel |e aut |
| 700 | 0 | 1 | |a Capurso Gabriele |e aut |
| 700 | 0 | 1 | |a Milanetto Anna Caterina |e aut |
| 700 | 0 | 1 | |a Gazouli Maria |e aut |
| 700 | 0 | 1 | |a Goetz Mara |e aut |
| 700 | 0 | 1 | |a Brenner Hermann |e aut |
| 700 | 0 | 1 | |a Vermeulen Roel C H |e aut |
| 700 | 0 | 2 | |a Talar-Wojnarowska Renata |e aut |
| 700 | 0 | 2 | |a Vanella Giuseppe |e aut |
| 700 | 0 | 2 | |a Tavano Francesca |e aut |
| 700 | 0 | 2 | |a Lucchesi Maurizio |e aut |
| 700 | 0 | 2 | |a Mohelnikova-Duchonova Beatrice |e aut |
| 700 | 0 | 2 | |a Chen Xuechen |e aut |
| 700 | 0 | 2 | |a Kiudelis Vytautas |e aut |
| 700 | 0 | 2 | |a Hegyi Péter |e aut |
| 700 | 0 | 2 | |a Oliverius Martin |e aut |
| 700 | 0 | 2 | |a Stocker Hannah |e aut |
| 700 | 0 | 2 | |a Stornello Caterina |e aut |
| 700 | 0 | 2 | |a Vodickova Ludmila |e aut |
| 700 | 0 | 2 | |a Souček Pavel |e aut |
| 700 | 0 | 2 | |a Neoptolemos John P |e aut |
| 700 | 0 | 2 | |a Testoni Sabrina Gloria Giulia |e aut |
| 700 | 0 | 2 | |a Morelli Luca |e aut |
| 700 | 0 | 2 | |a Lawlor Rita T |e aut |
| 700 | 0 | 2 | |a Basso Daniela |e aut |
| 700 | 0 | 2 | |a Izbicki Jakob R |e aut |
| 700 | 0 | 2 | |a Ermini Stefano |e aut |
| 700 | 0 | 2 | |a Szentesi Andrea Ildikó |e aut |
| 700 | 0 | 2 | |a Erőss Bálint Mihály |e aut |
| 700 | 0 | 2 | |a et al. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/29813/1/Peduzzi.pdf |z Dokumentum-elérés |