Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women

Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women

The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase asso...

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Bibliographic Details
Main Authors: Peduzzi Giulia
Archibugi Livia
Katzke Verena
Gentiluomo Manuel
Capurso Gabriele
Milanetto Anna Caterina
Gazouli Maria
Goetz Mara
Brenner Hermann
Vermeulen Roel C H
Talar-Wojnarowska Renata
Vanella Giuseppe
Tavano Francesca
Lucchesi Maurizio
Mohelnikova-Duchonova Beatrice
Chen Xuechen
Kiudelis Vytautas
Hegyi Péter
Oliverius Martin
Stocker Hannah
Stornello Caterina
Vodickova Ludmila
Souček Pavel
Neoptolemos John P
Testoni Sabrina Gloria Giulia
Morelli Luca
Lawlor Rita T
Basso Daniela
Izbicki Jakob R
Ermini Stefano
Szentesi Andrea Ildikó
Erőss Bálint Mihály
et al
Format: Article
Published: 2022
Series:SCIENTIFIC REPORTS 12 No. 1
Subjects:
Klinikai orvostan
doi:10.1038/s41598-022-22973-9

mtmt:33198988
Online Access:http://publicatio.bibl.u-szeged.hu/29813
Description
Summary:The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involved in oestrogen and pregnenolone biosynthesis and oestrogen-mediated signalling. In the discovery phase 14 polymorphisms showed a statistically significant association (P < 0.05). In the replication none of the findings were validated. In addition, a gene-based analysis was performed on the 208 selected genes. Four genes (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC risk, but only NR5A2 showed an association (P = 4.08 × 10-5) below the Bonferroni-corrected threshold of statistical significance. In conclusion, despite differences in incidence between males and females, our study did not identify an effect of common polymorphisms in the oestrogen and pregnenolone pathways in relation to PDAC susceptibility. However, we validated the previously reported association between NR5A2 gene variants and PDAC risk.
Physical Description:8
ISSN:2045-2322

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