Break up or wrap? Therapeutic Possibilities for the Treatment of Alzheimer´s disease by altering the aggregation of beta-amyloid peptide

The occurrence of Alzheimer´s disease (AD) grows dramatically with the mean age of the human population. This devastating neurodegenerative disorder causes an increasing financial burden on the individuals and the society. Currently existing therapies can provide only symptomatic relief by slowing d...

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Bibliographic Details
Main Authors: Fülöp Lívia
Penke Botond
Zarándi Márta
Format: Book part
Published: Research Signpost Trivandrum 2009
Series:Neuropeptides and peptide analogs
Subjects:
mtmt:1111797
Online Access:http://publicatio.bibl.u-szeged.hu/29524
Description
Summary:The occurrence of Alzheimer´s disease (AD) grows dramatically with the mean age of the human population. This devastating neurodegenerative disorder causes an increasing financial burden on the individuals and the society. Currently existing therapies can provide only symptomatic relief by slowing down the mental breakdown and improving cognitive and behavioral functions temporarily. AD is a so-called `protein misfolding disease´, as its course is strongly related to the production, aggregation, and consequent accumulation of a peptide named beta-amyloid (Aβ) in the brain. In this review, we summarize the results of the investigations that have aimed to alter the aggregation pathway of Aβ and present the most promising drug candidates possessing aggregation inhibitory activity, which could serve as efficient causative therapeutics in the future.
Physical Description:28
161-188
ISBN:9788130803173; 8130803178