DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation

DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation

DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (includ...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Jókai Mátyás
Torma Ferenc Gergely
McGreevy Kristen M.
Koltai Erika
Bori Zoltán
Bábszky Gergely
Bakonyi Péter
Gombos Zoltán
György Bernadett
Aczél Dóra Tímea
Tóth László
Osváth Péter
Fridvalszky Marcell
Téglás Tímea
Pósa Anikó
Kujach Sylwester
Olek Robert
Kawamura Takuji
Seki Yasuhiro
Suzuki Katsuhiko
Tanisawa Kumpei
Goto Sataro
Kerepesi Csaba
Boldogh Istvan
Ba Xueqing
Davies Kelvin J. A.
Horvath Steve
Radák Zsolt
Dokumentumtípus: Cikk
Megjelent: 2023
Sorozat:GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) 45 No. 5
Tárgyszavak:
Biológiai tudományok
doi:10.1007/s11357-023-00826-1

mtmt:33866054
Online Access:http://publicatio.bibl.u-szeged.hu/29377
Leíró adatok
Tartalmi kivonat:DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax ( p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax ( ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels ( ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.
Terjedelem/Fizikai jellemzők:2805-2817
ISSN:2509-2715

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