Fatty Pancreas Is a Risk Factor for Pancreatic Cancer A Systematic Review and Meta-Analysis of 2956 Patients /

Pancreatic cancer (PC) is one of the most lethal cancers worldwide. Recently, fatty pancreas (FP) has been studied thoroughly, and although its relationship to PC is not fully understood, FP is suspected to contribute to the development of PC. We aimed to assess the association between PC and FP by...

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Bibliographic Details
Main Authors: Lipp Mónika Bernadett
Tarján Dorottya
Lee Jimin
Zolcsák Ádám
Szalai Eszter
Teutsch Brigitta
Faluhelyi Nándor
Erőss Bálint Mihály
Hegyi Péter
Mikó Alexandra
Format: Article
Published: 2023
Series:CANCERS 15 No. 19
Subjects:
doi:10.3390/cancers15194876

mtmt:34211988
Online Access:http://publicatio.bibl.u-szeged.hu/29106
Description
Summary:Pancreatic cancer (PC) is one of the most lethal cancers worldwide. Recently, fatty pancreas (FP) has been studied thoroughly, and although its relationship to PC is not fully understood, FP is suspected to contribute to the development of PC. We aimed to assess the association between PC and FP by conducting a systematic review and meta-analysis. We systematically searched three databases, MEDLINE, Embase, and CENTRAL, on 21 October 2022. Case-control and cross-sectional studies reporting on patients where the intra-pancreatic fat deposition was determined by modern radiology or histology were included. As main outcome parameters, FP in patients with and without PC and PC in patients with and without FP were measured. Proportion and odds ratio (OR) with a 95% confidence interval (CI) were used for effect size measure. PC among patients with FP was 32% (OR 1.32; 95% CI 0.42-4.16). However, the probability of having FP among patients with PC was more than six times higher (OR 6.13; 95% CI 2.61-14.42) than in patients without PC, whereas the proportion of FP among patients with PC was 0.62 (95% CI 0.42-0.79). Patients identified with FP are at risk of developing PC. Proper screening and follow-up of patients with FP may be recommended.
Physical Description:14
ISSN:2072-6694