Predictive Potential of RNA Polymerase B (II) Subunit 1 (RPB1) Cytoplasmic Aggregation for Neoadjuvant Chemotherapy Failure
We aimed to investigate the contribution of co-translational protein aggregation to the chemotherapy resistance of tumor cells. Increased co-translational protein aggregation reflects altered translation regulation that may have the potential to buffer transcription under genotoxic stress. As an ind...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
24 No. 21 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms242115869 |
| mtmt: | 34230980 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/28563 |
| LEADER | 02688nab a2200469 i 4500 | ||
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| 024 | 7 | |a 34230980 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
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| 100 | 2 | |a Nagy-Mikó Bence | |
| 245 | 1 | 0 | |a Predictive Potential of RNA Polymerase B (II) Subunit 1 (RPB1) Cytoplasmic Aggregation for Neoadjuvant Chemotherapy Failure |h [elektronikus dokumentum] / |c Nagy-Mikó Bence |
| 260 | |c 2023 | ||
| 300 | |a 9 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 24 No. 21 | |
| 520 | 3 | |a We aimed to investigate the contribution of co-translational protein aggregation to the chemotherapy resistance of tumor cells. Increased co-translational protein aggregation reflects altered translation regulation that may have the potential to buffer transcription under genotoxic stress. As an indicator for such an event, we followed the cytoplasmic aggregation of RPB1, the aggregation-prone largest subunit of RNA polymerase II, in biopsy samples taken from patients with invasive carcinoma of no special type. RPB1 frequently aggregates co-translationally in the absence of proper HSP90 chaperone function or in ribosome mutant cells as revealed formerly in yeast. We found that cytoplasmic foci of RPB1 occur in larger sizes in tumors that showed no regression after therapy. Based on these results, we propose that monitoring the cytoplasmic aggregation of RPB1 may be suitable for determining—from biopsy samples taken before treatment—the effectiveness of neoadjuvant chemotherapy. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Szatmári Orsolya |e aut |
| 700 | 0 | 2 | |a Faragó-Mészáros Réka |e aut |
| 700 | 0 | 2 | |a Csókási Aliz |e aut |
| 700 | 0 | 2 | |a Bognár Bence |e aut |
| 700 | 0 | 2 | |a Ördög Nóra |e aut |
| 700 | 0 | 2 | |a Borsos Barbara Nikolett |e aut |
| 700 | 0 | 2 | |a Majoros Hajnalka |e aut |
| 700 | 0 | 2 | |a Újfaludi Zsuzsanna |e aut |
| 700 | 0 | 2 | |a Oláh Orsolya |e aut |
| 700 | 0 | 2 | |a Nikolényi Alíz |e aut |
| 700 | 0 | 2 | |a Dobi Ágnes |e aut |
| 700 | 0 | 2 | |a Kószó Renáta Lilla |e aut |
| 700 | 0 | 2 | |a Sántha Dóra |e aut |
| 700 | 0 | 2 | |a Lázár György ifj |e aut |
| 700 | 0 | 2 | |a Simonka Zsolt |e aut |
| 700 | 0 | 2 | |a Paszt Attila |e aut |
| 700 | 0 | 2 | |a Ormándi Katalin |e aut |
| 700 | 0 | 2 | |a Pankotai Tibor |e aut |
| 700 | 0 | 2 | |a Boros Imre Miklós |e aut |
| 700 | 0 | 2 | |a Villanyi Zoltan |e aut |
| 700 | 0 | 2 | |a Vörös András |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/28563/1/Nagy-MikoBence...LazarSimonkaPaszt...PredictivePotentialofRNAPolymeraseBIISubunit1RPB1CytoplasmicAggregationforNeoadjuvant.pdf |z Dokumentum-elérés |