Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue

Astaxanthin is a lipid-soluble carotenoid influencing lipid metabolism, body weight, and insulin sensitivity. We provide a systematic analysis of acute and chronic effects of astaxanthin on different organs. Changes by chronic astaxanthin feeding were analyzed on general metabolism, expression of re...

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Bibliographic Details
Main Authors: Gönczi Mónika
Csemer Andrea
Szabó László
Sztretye Mónika
Fodor János
Deák-Pocsai Krisztina
Szenthe Kálmán
Keller-Pintér Anikó
Köhler Zoltán Márton
Nánási Péter Pál
Szentandrássy Norbert
Pál Balázs Zoltán
Csernoch László
Format: Article
Published: 2022
Series:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 No. 2
Subjects:
doi:10.3390/ijms23020917

mtmt:32613311
Online Access:http://publicatio.bibl.u-szeged.hu/28162
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Summary:Astaxanthin is a lipid-soluble carotenoid influencing lipid metabolism, body weight, and insulin sensitivity. We provide a systematic analysis of acute and chronic effects of astaxanthin on different organs. Changes by chronic astaxanthin feeding were analyzed on general metabolism, expression of regulatory proteins in the skeletal muscle, as well as changes of excitation and synaptic activity in the hypothalamic arcuate nucleus of mice. Acute responses were also tested on canine cardiac muscle and different neuronal populations of the hypothalamic arcuate nucleus in mice. Dietary astaxanthin significantly increased food intake. It also increased protein levels affecting glucose metabolism and fatty acid biosynthesis in skeletal muscle. Inhibitory inputs innervating neurons of the arcuate nucleus regulating metabolism and food intake were strengthened by both acute and chronic astaxanthin treatment. Astaxanthin moderately shortened cardiac action potentials, depressed their plateau potential, and reduced the maximal rate of depolarization. Based on its complex actions on metabolism and food intake, our data support the previous findings that astaxanthin is suitable for supplementing the diet of patients with disturbances in energy homeostasis.
Physical Description:19
ISSN:1661-6596