Studies on the neurotoxicity of arsenic in rats in different exposure timing schemes

Arsenic has long been recognized as human poison and, more recently, as an essential micronutrient. Here, the effects of low-level arsenic exposure on the central and peripheral nervous system functions were studied in rats, in a 4-8-12-week subchronic exposure scheme, and in a 3-generation scheme i...

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Bibliographic Details
Main Authors: Szabó Andrea
Lengyel Zs
Lukács Anita
Papp András
Format: Article
Published: 2006
Series:TRACE ELEMENTS AND ELECTROLYTES 23 No. 3
Subjects:
doi:10.5414/TEP23193

mtmt:1240514
Online Access:http://publicatio.bibl.u-szeged.hu/27639
Description
Summary:Arsenic has long been recognized as human poison and, more recently, as an essential micronutrient. Here, the effects of low-level arsenic exposure on the central and peripheral nervous system functions were studied in rats, in a 4-8-12-week subchronic exposure scheme, and in a 3-generation scheme involving treatment of the parents and the offspring. From the rats, spontaneous and evoked activity of the sensory cortical areas, and compound action potential from the tail nerve, was recorded in urethane anesthesia, then dissection with organ weight measurement was done. Body weight gain of the treated animals did not differ significantly from the control. There were, however, dose-dependent changes in the weight of the liver and other organs. Latency of the cortical-evoked potentials increased in the treated rats in both schemes. The change was significant after long exposure times and in the higher dose groups. A shift of the spontaneous cortical activity to higher frequencies was also observed, with similar dose- and time dependence. Low-level arsenic affected the behavioral and electrophysiological functions in the brain, indicating that long-lasting arsenic exposure can result in manifest alteration of the central and peripheral nervous system. Consequently, arsenic-exposed populations may have a higher risk of behavioral and functional neurotoxic effects and potentially be an additive to the neurotoxicity of other environmental xenobiotics. Š2006 Dustri-Verlag.
Physical Description:193-196
ISSN:0946-2104