Seasonality and Delirium Tremens in Hospitalized Patients with Alcohol Dependence Syndrome

<b><i>Introduction:</i></b> Due to the high rate of mortality, recognizing the contributing factors of alcohol-related delirium tremens (DT), which is the most severe form of alcohol withdrawal state (AWS) is pivotal in clinical settings. Previous studies suggested relationsh...

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Main Authors: Pribék Ildikó Katalin
Kádár Bettina Kata
Péter Lea
Daróczy Júlia
Bajsz András
Kovács Csenge Sára
Demeter Ildikó
Janka Zoltán
Urbán Róbert
Demetrovics Zsolt
Lázár Bence András
Kovács Ildikó
Kálmán János
Andó Bálint
Format: Article
Published: 2023
Series:EUROPEAN ADDICTION RESEARCH 29 No. 2
Subjects:
doi:10.1159/000527973

mtmt:33595646
Online Access:http://publicatio.bibl.u-szeged.hu/26752
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Summary:<b><i>Introduction:</i></b> Due to the high rate of mortality, recognizing the contributing factors of alcohol-related delirium tremens (DT), which is the most severe form of alcohol withdrawal state (AWS) is pivotal in clinical settings. Previous studies suggested relationship between seasonality and other types of delirium; however, to our knowledge, this is the first empirical study which examined the role of seasonality in DT in alcohol dependence syndrome (ADS). <b><i>Methods:</i></b> A retrospective study was undertaken between 2008 and 2015; medical records of 1,591 patients were included, which yielded 2,900 hospital appearances. Three groups were formed based on the ICD-10 diagnoses: ADS, AWS, and DT. The characteristics of the groups were analysed with one-way ANOVA and χ<sup>2</sup> tests. Multinomial logistic regression was used to explore the potential predictors of DT, including seasonality. <b><i>Results:</i></b> The highest incidence of DT was in spring (36.8%; χ<sup>2</sup> (3) = 27.666; <i>p</i> < 0.001), especially in March (13.9%; χ<sup>2</sup> (11) = 33.168; <i>p</i> < 0.001). Spring, higher mean age, higher presence of comorbid somatic disorders, and lower occurrence of comorbid psychiatric disorders were significant predictive variables for DT with the control of socio-demographic and clinical variables. <b><i>Conclusions:</i></b> The present study revealed that spring, especially March is a critical period in temperate climate zone regarding DT. This can be interpreted as a late winter effect since the temperature is lower in this month compared to other spring months. Furthermore, higher age and the occurrence of comorbid somatic disorders can be considered as risk factors in case of DT. These results support the need of further clinical studies to better understand the impact of seasonality on DT.
Physical Description:83-91
ISSN:1022-6877