Predictive role of neostromal CD10 expression in breast cancer patients treated with neoadjuvant chemotherapy

Background: The therapeutic strategy of invasive breast cancer is based on routine histopathological markers (estrogen-, progesterone receptor, HER2, Ki67) routinely evaluated in tumor cells. However, the assessment of cancer stroma could influence therapeutic strategies. Studies have shown that str...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Oláh Orsolya
Majlat Edit
Kószó Renáta Lilla
Veréb Zoltán
Vörös András
Dokumentumtípus: Cikk
Megjelent: 2023
Sorozat:PATHOLOGY AND ONCOLOGY RESEARCH 28
Tárgyszavak:
doi:10.3389/pore.2022.1610598

mtmt:33550115
Online Access:http://publicatio.bibl.u-szeged.hu/26637
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520 3 |a Background: The therapeutic strategy of invasive breast cancer is based on routine histopathological markers (estrogen-, progesterone receptor, HER2, Ki67) routinely evaluated in tumor cells. However, the assessment of cancer stroma could influence therapeutic strategies. Studies have shown that stromal expression of CD10, a zinc-dependent metalloproteinase, is associated with biological aggressiveness of the tumor. In the present retrospective study, we aimed to evaluate stromal CD10 expression and association between CD10 expression and response to neoadjuvant chemotherapy in invasive breast cancer. 
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