Predictive role of neostromal CD10 expression in breast cancer patients treated with neoadjuvant chemotherapy
Background: The therapeutic strategy of invasive breast cancer is based on routine histopathological markers (estrogen-, progesterone receptor, HER2, Ki67) routinely evaluated in tumor cells. However, the assessment of cancer stroma could influence therapeutic strategies. Studies have shown that str...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
|
| Sorozat: | PATHOLOGY AND ONCOLOGY RESEARCH
28 |
| Tárgyszavak: | |
| doi: | 10.3389/pore.2022.1610598 |
| mtmt: | 33550115 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/26637 |
| Tartalmi kivonat: | Background: The therapeutic strategy of invasive breast cancer is based on routine histopathological markers (estrogen-, progesterone receptor, HER2, Ki67) routinely evaluated in tumor cells. However, the assessment of cancer stroma could influence therapeutic strategies. Studies have shown that stromal expression of CD10, a zinc-dependent metalloproteinase, is associated with biological aggressiveness of the tumor. In the present retrospective study, we aimed to evaluate stromal CD10 expression and association between CD10 expression and response to neoadjuvant chemotherapy in invasive breast cancer. |
|---|---|
| Terjedelem/Fizikai jellemzők: | 8 |
| ISSN: | 1219-4956 |