Synthesis and In Vitro Anticancer Evaluation of Flavone—1,2,3-Triazole Hybrids
Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hyb...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | MOLECULES
28 No. 2 |
| Tárgyszavak: | |
| doi: | 10.3390/molecules28020626 |
| mtmt: | 33550341 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/26385 |
| Tartalmi kivonat: | Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect. |
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| Terjedelem/Fizikai jellemzők: | 16 |
| ISSN: | 1420-3049 |