Új eljárás a nem melanoma típusú bőrdaganatok kezelésében "daylight" fotodinámiás terápia /
Photodynamic therapy is indicated for the treatment of superficial basal cell carcinoma, Bowen's disease and actinic keratosis. Reactive oxygen radicals are released from the metabolite of the topically applied photosensitizer that is excited by light, which selectively leads to the destruction...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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2022
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| Sorozat: | ORVOSI HETILAP
163 No. 36 |
| Tárgyszavak: | |
| doi: | 10.1556/650.2022.32554 |
| mtmt: | 33088902 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/25301 |
| Tartalmi kivonat: | Photodynamic therapy is indicated for the treatment of superficial basal cell carcinoma, Bowen's disease and actinic keratosis. Reactive oxygen radicals are released from the metabolite of the topically applied photosensitizer that is excited by light, which selectively leads to the destruction of tumor cells. The procedure can be performed with an artificial light source or with the use of sunlight. The latter is called daylight photodynamic therapy, which is an effective and painless procedure.Our aim was to introduce daylight photodynamic therapy in actinic keratoses at our department and to optimize the treatment protocol for the local climatic conditions.Three clinical trials were performed. The difference between the treatment protocols was between the incubation time of the photosensitizer on the skin and in the time patients spent under the sunlight.When using the international treatment protocol, 73% of the actinic keratoses showed complete, while 27% partial remission. By reducing the proportion of time patients spent outdoor, complete remission was achieved in two-thirds and partial remission in one-third of the lesions. At doses above 100 J/cm², severe erythema was observed 24 hours after the treatment. To avoid this, we calculated the time to be spent outdoor by dosimetry. Partial remission was achieved in 15%, complete remission in 85% of the actinic keratoses with good tolerability.The stepwise modification of the treatment protocol resulted in an effective and well-tolerated treatment in actinic keratoses under the local climatic conditions.The method has been successfully adapted in our clinic and is used in daily practice to treat actinic keratoses. Orv Hetil. 2022; 163(36): 1422-1429. |
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| Terjedelem/Fizikai jellemzők: | 1422-1429 |
| ISSN: | 0030-6002 |