Gastroenteropancreatic Neuroendocrine Neoplasms in Patients with Inflammatory Bowel Disease An ECCO CONFER Multicentre Case Series /
Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) have rarely been reported in association with inflammatory bowel diseases (IBDs).An ECCO COllaborative Network For Exceptionally Rare case reports project (ECCO-CONFER) collecting cases of GEP-NENs diagnosed in patients with IBD.GEP-NEN was...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2022
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| Sorozat: | JOURNAL OF CROHNS & COLITIS
16 No. 6 |
| Tárgyszavak: | |
| doi: | 10.1093/ecco-jcc/jjab217 |
| mtmt: | 32539446 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/23064 |
| Tartalmi kivonat: | Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) have rarely been reported in association with inflammatory bowel diseases (IBDs).An ECCO COllaborative Network For Exceptionally Rare case reports project (ECCO-CONFER) collecting cases of GEP-NENs diagnosed in patients with IBD.GEP-NEN was diagnosed in 100 IBD patients [61% female, 55% Crohn's disease, median age 48 years (IQR 38-59)]. The most common location was the appendix (39%) followed by the colon (22%).Comprehensive IBD-related data was available for 50 individuals with a median follow-up of 30 months (IQR 11-70) following NEN diagnosis. Median duration of IBD at NEN diagnosis was 84 months (IQR 10-151), and in 18% of cases NEN and IBD were diagnosed concomitantly. At diagnosis, 20/50 were stage-I (T1N0M0), and 28/50 graded G1 (ki67≤2%).Incidental diagnosis of NEN and concomitantly with IBD diagnosis were associated with an earlier NEN stage (p=0.01 and p = 0.02, respectively). Exposure to immunomodulatory or biologic therapy was not associated with advanced NEN stage or grade. Primary GEP-NEN were more frequently found in the segment affected by IBD (62% vs. 38%). At the last follow-up data, 47/50 patients were alive, and only two deaths were related to NEN.In the largest case series to date, prognosis of patients with GEP-NEN and IBD seems favorable. Incidental NEN diagnosis correlates with an earlier NEN stage and IBD-related therapies are probably independent of NEN stage and grade. The association of GEP-NEN location and the segment affected by IBD may suggest a possible role of inflammation in NEN tumourigenesis. |
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| Terjedelem/Fizikai jellemzők: | 940-945 |
| ISSN: | 1873-9946 |