Protection against anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade
Data in the literature concerning the role of Kupffer cells in anaphylaxis are contradictory. In the present study the effect of Kupffer cell blockade induced by gadolinium chloride (GdCl3) on anaphylactic shock was investigated. Our observations show that GdCl3 prevents lethal anaphylactic shock in...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
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| Sorozat: | JOURNAL OF ALLOYS AND COMPOUNDS
225 No. 1-2 |
| doi: | 10.1016/0925-8388(94)07075-X |
| mtmt: | 1433478 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/21445 |
| Tartalmi kivonat: | Data in the literature concerning the role of Kupffer cells in anaphylaxis are contradictory. In the present study the effect of Kupffer cell blockade induced by gadolinium chloride (GdCl3) on anaphylactic shock was investigated. Our observations show that GdCl3 prevents lethal anaphylactic shock in mice sensitized to ovalbumin. Gadolinium chloride given i.v. in a dose of 1 mg (100 g)(-1) body weight 24 or 48 h before the elicitation of anaphylactic shock resulted in 80% survival, compared with the 43% survival in the control group. The same dose of gadolinium chlorde and also other rare earth metal salts, like lanthanum-, praseodymium-, neodymium-, and european chlorides given i.v., one day before the elicitation of anaphylactic shock, greatly reduced the mortality in mice sensitized with ovalbumin and Bordatella pertussis vaccine. However, gadolinium chloride given, per os, in a dose of 2 mg (100 g)(-1) body weight, one or two days before the elicitation of anaphylactic shock were ineffective. Gadolinum chloride similarly abrogated the symptoms of anaphylaxis, including the accumulation of serotonin and histamine in the liver. The results suggest that Kupffer cells play an important role in mouse anaphylaxis. |
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| Terjedelem/Fizikai jellemzők: | 619-622 |
| ISSN: | 0925-8388 |