Successful Treatment of Multiple Basaliomas with Bleomycin-based Electrochemotherapy A Case Series of Three Patients with Gorlin-Goltz Syndrome. /
Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemo-therapy is a novel therapeuti...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2012
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| Sorozat: | ACTA DERMATO-VENEREOLOGICA
92 No. 6 |
| doi: | 10.2340/00015555-1361 |
| mtmt: | 1965286 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/21403 |
| Tartalmi kivonat: | Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemo-therapy is a novel therapeutic option that ablates tumours with electrical current and simultaneously administered anticancer drugs. Three patients with Gorlin-Goltz syndrome were treated with electrochemotherapy using intravenous bleomycin. Clinical response was obtained in 98 (99%) of the lesions, 86 (87%) of them showed complete response. In 2 tumours, regression was confirmed with histological examination. Long-term cosmetic results were excellent. We consider electrochemotherapy to be an additional tool in the therapeutic armamentarium for Gorlin-Goltz syndrome, and suggest using it as early as possible in selected patients to avoid disfiguring scarring. |
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| Terjedelem/Fizikai jellemzők: | 648-651 |
| ISSN: | 0001-5555 |