Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis a cross-sectional multicentre international study with experimental animal model /

Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divid...

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Main Authors: Hegyi Péter Jenő
Soós Alexandra
Tóth Emese
Ébert Attila
Venglovecz Viktória
Márta Katalin
Mátrai Péter
Mikó Alexandra
Bajor Judit
Sarlós Patrícia
Vincze Áron
Halász Adrienn
Izbéki Ferenc
Szepes Zoltán
Czakó László
Kovács György
Papp Mária
Dubravcsik Zsolt
Hamvas József
Németh Balázs
Macarie Melania
Ince Ali Tüzün
Bordin Dmitry S.
Dubtsova Elena A.
Kiryukova Mariya A.
Khatkov Igor E.
Bideeva Tanya
Mickevicius Artautas
Ramírez‑Maldonado Elena
Sallinen Ville
Erőss Bálint Mihály
Pécsi Dániel
Szentesi Andrea Ildikó
Párniczky Andrea
Tiszlavicz László
Hegyi Péter
Format: Article
Published: 2021
Series:SCIENTIFIC REPORTS 11 No. 1
doi:10.1038/s41598-020-80532-6

mtmt:31815619
Online Access:http://publicatio.bibl.u-szeged.hu/21187
Description
Summary:Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
Physical Description:Terjedelem: 14 p-Azonosító: 1367
ISSN:2045-2322