Terápiás szekvenciák az előrehaladott/áttétes prosztatadaganatok gyógyszeres kezelésében [Therapeutic sequences in the treatment of advanced/metastatic prostate cancer]

The unprecedented development of prostate cancer therapy is a challenge for the proper sequential use of modern medicines. Patients' life expectancies improve when we use treatment lines, one after the other. There is no evidence- based guideline regarding the optimal sequence, but a number of...

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Bibliographic Details
Main Authors: Maráz Anikó
Géczi Lajos
Bíró Krisztina
Varga Linda
Küronya Zsófia
Format: Article
Published: 2020
Series:MAGYAR ONKOLÓGIA 64 No. 3
mtmt:31611616
Online Access:http://publicatio.bibl.u-szeged.hu/19652
Description
Summary:The unprecedented development of prostate cancer therapy is a challenge for the proper sequential use of modern medicines. Patients' life expectancies improve when we use treatment lines, one after the other. There is no evidence- based guideline regarding the optimal sequence, but a number of data are available to help the physician selecting the best individualized therapeutic option. The basic treatment for advanced prostate cancer is still androgenic deprivation (ADT), to which we can add additional therapeutic agents. New types of hormonal (androgen receptor targeted, ARTA) agents are being used in an increasingly early line. Chemotherapy (CT) is the first choice in case of metastatic, hormone-sensitive disease especially in high volume cases that are causing symptoms or visceral crisis. CT is otherwise applied after ARTA. We have little but encouraging data about the early, sequential use of ARTAs with different mechanisms of action. In later lines, cross-resistance may develop between ARTA treatments, in which cases CT is the right decision. In this paper, we summarize the results of clinical trials that may help in therapeutic decision making, maximizing the benefits for patients.
Physical Description:263-272
ISSN:0025-0244