Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations
Whereas specialist major histocompatibility complex (MHC) molecules initiate immune response against only relatively few pathogens, generalists provide protection against a broad range. Accordingly, this study shows that the geographical distribution of generalist MHC alleles in human populations re...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | PLOS BIOLOGY
17 No. 1 |
| doi: | 10.1371/journal.pbio.3000131 |
| mtmt: | 30420930 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/19166 |
| Tartalmi kivonat: | Whereas specialist major histocompatibility complex (MHC) molecules initiate immune response against only relatively few pathogens, generalists provide protection against a broad range. Accordingly, this study shows that the geographical distribution of generalist MHC alleles in human populations reflects exposure to diverse infectious diseases. |
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| Terjedelem/Fizikai jellemzők: | Azonosító: e3000131-Terjedelem: 21 p. |
| ISSN: | 1544-9173 |