N-Acetylation of Amines in Continuous-Flow with Acetonitrile-No Need for Hazardous and Toxic Carboxylic Acid Derivatives

A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good co...

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Bibliographic Details
Main Authors: Orsy György
Fülöp Ferenc
Mándity István M.
Format: Article
Published: 2020
Series:MOLECULES 25 No. 8
doi:10.3390/molecules25081985

mtmt:31346572
Online Access:http://publicatio.bibl.u-szeged.hu/18994
Description
Summary:A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good conversion. The catalyst showed excellent reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol) was also synthesized with good conversion and yield.
Physical Description:Azonosító: 1985-Terjedelem: 12
ISSN:1420-3049